抗驚厥藥物使人想自殺

抗驚厥藥物使人想自殺
Anticonvulsant drug makes people want to kill themselves
David Gutierrez
Natural News
Tuesday, August 31, 2010

(NaturalNews) Popular anti-seizure drugs may seriously increase a patient's risk of suicide and violent death, according to a study conducted by researchers from Brigham and Women's Hospital and Harvard Medical School, and published in the Journal of the American Medical Association.
（NaturalNews）流行的抗腦癇藥物可能會嚴重地增加病人的自殺風險和暴力死亡，據一項由布里格姆與婦女醫院和哈佛醫學院的研究人員進行的研究，並發表在美國醫學協會雜誌。
The drugs, known as anticonvulsants, were initially designed for the treatment of epilepsy but are now widely prescribed "off-label" for conditions such as bipolar disorder, migraine headaches and pain.
被稱為抗驚厥藥的藥物，最初設計用於治療腦癇，但現在被廣泛地“冇標示”處方，用於情况例如雙相情感障礙、偏頭痛和疼痛。
"We all know the range of uses of these medications is very, very wide," researcher Elisabetta Patorno said.
“我們都知道這些藥物的使用範圍是非常，非常廣泛，”研究人員伊麗莎白 Patorno說。
The researchers examined the prescription and medical records of more than 300,000 people above the age of 14 who had been prescribed an anticonvulsant for the first time between July 2001 and December 2006.
研究人員檢查超過 30萬年齡在14以上的人的處方和病歷，他們被處方一種抗驚厥藥，首次在2001年7月至2006年12月之間。
All of the drugs, they found, significantly increased a patient's risk of attempted or successful suicide, as well as violent death by other causes. During the course of the study, there were 801 attempted suicides, 26 successful suicides and 41 violent deaths.
他們發現所有的藥物，顯著增加病人企圖或成功自殺的風險，以及因其它原因而暴力死亡。在研究過程中，有801人企圖自殺，26宗自殺成功的和41宗暴力死亡事件。
"We found increased risk for suicidal acts beginning within the first 14 days after treatment initiation, opening the possibility that anticonvulsant medications could induce behavioral effects prior to the achievement of their full therapeutic effectiveness," the researchers wrote.
“我們發現對自殺行為的風險增加，在開始治療後的首14天之內，開設那可能性抗腦癇藥物可能導致行為上的影響，在它們完全的治療效果達成之前，”研究人員寫道。
Based on prior studies, the FDA ruled in 2008 that all anticonvulsants must carry labels warning that they double the risk of suicidal thoughts and actions. These older studies had not been able to determine if any drugs posed higher risks than others, however.

In the current study, researchers compared the rates of suicides and violent deaths among users of topiramate (sold generically and also marketed as Topamax), gabapentin (marketed as Neurontin), lamotrigine (marketed as Lamictal), oxcarbazepine (marketed as Trileptal), tiagabine (marketed as Gabitril) and valproate (marketed as Depakine and Epilim). They found that the risk was lowest in topiramate, and roughly equal in the five other drugs.


Sources for this story include: http://www.reuters.com/article/idUS…

http://www.naturalnews.com/029614_suicide_anti-seizure_drugs.html