嚴重和致命的H1N1病毒在以往是健康的年輕成人

嚴重和致命的H1N1病毒在以往是健康的年輕成人
Severe and Fatal H1N1 In Previously Healthy Young Adults
Recombinomics Commentary 22:00
December 16, 2010
Tran slation by Autumnson Blog

There have been reported four serious cases of confirmed hospitalized AnH1N1 influenza virus, they are all men aged 24-57 years who had no risk factors and were admitted to the ICU between 5 and 11 December.
已有報告四宗嚴重的確診住院AnH1N1流感病毒病例，他們都是年齡在 24-57歲的男子，他們都沒有風險因素及在12月5至11日間被送進加護病房。
Up to week 49/2010 there have been nine severe cases confirmed and hospitalized, all men and 89% without risk factors.
截至二Ｏ一Ｏ年四十九週，已有九宗嚴重病例確診和住院，全是男人和89％沒有風險因素。
The figures reveal all of the flu victims were aged under 65 and six were under 18 years-old.
數字顯示所有的流感受害者年齡都在65歲以下，及六人未滿 18歲。
At least eight of the 17 fatal cases was in an "at-risk" group - such as somebody with diabetes or asthma - but none were pregnant.
17宗死亡個案至少有8 宗是在一“高風險”群體 - 例如患有糖尿病或哮喘的人 - 但沒有懷孕的。
The above comments from week 49 reports out of Spain and the United Kingdom highlight severe and fatal H1N1 cases this season. Spain is trailing the UK, and the week 49 report from the UK is trailing the HPA report due to the spike in severe and fatal cases in the past week.
上述來自 西班牙和英國49週報告的評論，亮點本季嚴重和致命的H1N1病例。西班牙在尾隨英國，和該來自英國的49週報告是跟隨HPA報告，由於在過去一周的嚴重和致命病例高升。
As seen last year, these cases are heavily concentrated in patients less than 65, but this year the frequency of cases without underlying conditions is on the rise. The underlying conditions are broadly applied, although the more severe and fatal cases are concentrated in the cases with more severe conditions. Thus, obese cases are concentrated in the morbidly obese and most pregnant patients are in their third trimester, but the “underlying condition" category includes all obese patients and all pregnant patients, so the frequency of severe cases with these conditions is high. However, as seen above, even with the broad definition of underlying condition, the majority of the cases cited above do not have underlying conditions.

The increased targeting of healthy young adults, as well as the rapid rise in severe and fatal cases, when the H1N1 levels in the entire population are relatively low, raises concerns that the H1N1 has changed and become more virulent in the UK and Spain, with similar results to follow in other countries in the northern hemisphere.

This increased virulence has been noted previously for H1N1 with the receptor binding domain change D225G, which was strongly associated with severe and fatal cases last season. A change in the frequency of H1N1 with D225G could dramatically increase the frequency of severe and fatal cases. This type of change could be linked to other receptor binding changes that would be seen in the sequences associated with these recent cases.

D225G was predicted in severe and fatal cases in Ukraine and was present in all four fatal cases when initial sequences were released. It was also correctly predicted to be in death clusters, such as the fatal cases at Duke Medical Center. Similarly, D225G was in two of the five sequences from fatal lung infections in 1918.

Therefore, the immediate release of the sequences associated with the severe and fatal cases is warranted.

http://www.recombinomics.com/News/12161004/H1N1_Severe_Healthy.html

甲型H1N1流感在英國卷土重來殺10英人 醫界震驚

甲型流感在英國24人死亡 向歐洲蔓延